While this is presented in the context of a comic strip, I think there are some valuable take-aways as you look to establish your personal brand on Twitter. Although I'm sure I've been guilty of a few of these tendencies over 2,500 tweets during the past 3 years, it's worth thinking about whether what you're saying on Twitter really adds any value to the conversation.
To be sure, not everything you post on Twitter has to have intrinsic news-worthiness. Part of the beauty of the service is that it adds a human element to users that sometimes may be abstracted. But as you grow your follower base, keep in mind that you have an audience and think about why these users began to follow you in the first place.
If you're interested in some of the academic underpinnings, check out this study from Rutgers published earlier this year. It draws a distinction between "meformers" who talk about themselves, and "informers" who share information. One isn't necessarily better than the other, but informers tend to have a much larger and engaged audience than meformers.